Recent studies and clinical trials on Hyal-Joint that prove the effectiveness of Hyal-Joint include positive findings that may aid manufacturers interested in making claims. Some of these highlights include:

• A randomized, double-blind, placebo-controlled clinical trial was carried out to evaluate the efficacy and safety of Hyal-Joint compared with placebo for improvements in quality of life in adults with osteoarthritis of the knee. Researchers saw both physical and emotional improvement in patients, which increased quality of life, as well as their ability to perform activities and daily living.

• A study was conducted to determine the differences between Hyal-Joint and hyaluronic acid (HA) produced by bacterial fermentation in the stimulation of the synthesis of endogenous hyaluronic acid (eHA) by human synoviocytes. It concluded that at the same concentration levels of each product, the highest levels of eHA was measured in the cells stimulated with Hyal-Joint.

• A study to determine the intestinal absorption of Hyal-Joint using an everted gut sac model concluded that Hyal-Joint is absorbed from the medium through the intestinal mucous membrane.

• A study of the effect of Hyal-Joint on synovial fluid concluded that Hyal-Joint increases intracellular HA, which would be followed by HA secretion into the extracellular space. Therefore, Hyal-Joint may stimulate HA secretion to synovial fluid and improve joint function.

• A study on the chondroprotective effects of Hyal-Joint concluded that the use of Hyal-Joint can reduce inflammation. It significantly lowered prostaglandin E2 (PGE2) levels and showed a tendency to lower metalloproteinase 1 (MMP-1) levels, thus indicating Hyal-Joint to have chondroprotective effects.

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